In the context of sepsis, organ failure is associated with a poor outcome of the patient. The ProFS2 study prospectively examined 341 Patients in the early stage of a community acquired sepsis for organ failure. For 207 patients there was an evaluation of Brain Natriuretic Peptide (BNP) at the moment of hospitalization. The BNP-levels of patients who die within 30 days and survivors differ significantly. For patients in an early stage of a community acquired sepsis there is a correlation between the high of BNP-levels and mortality, the need of dialysis and the need of mechanical ventilation in clinical course. In the multivariate regression model, the severity of illness is the strongest predictor of the patient’s outcome.